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Effect of phytomedicines, AM1, niprisan® and nifadin on the pharmacokinetics of chloroquine in rats

Effect of phytomedicines, AM1, niprisan® and nifadin on the pharmacokinetics of chloroquine in rats,10.1007/BF03191166,European Journal of Drug Metabo

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Effect of phytomedicines, AM1, niprisan® and nifadin on the pharmacokinetics of chloroquine in rats  
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Summary  The single oral dose pharmacokinetics of chloroquine was studied alone and after coadministration with phytomedicines NIPRID/92/001/1-1 (AM-1), Niprisan®, and Nifadin® in rats. Plasma chloroquine concentrations were measured using High performance liquid chromatography (HPLC) method developed earlier in our laboratory. The data were fitted into a WinNonlin standard non-compartmental programme. The co-administration of the herbal medicines with chloroquine produced decrease in the serum concentration of chloroquine at each sampling time. The highest decrease of 85% occurring at the time of peak concentration (lh) was recorded with NifadinR, followed by 75% with NiprisanR, the least was 50% with AM-1. Significant reduction was also observed in some other parameters, such as area under the serum concentration- time curve ((AUC 0–24) and maximum serum concentration (C max ) while the apparent volume of distribution (V d ) and elimination half-life (t 1/2β) increased significantly (P< 0.05). It was concluded that the gastric presence of the herbal medicines significantly impaired the absorption of chloroquine in rats.
Journal: European Journal of Drug Metabolism and Pharmacokinetics - EUR J DRUG METAB PHARM , vol. 34, no. 3, pp. 151-155, 2009
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