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Trace Metal Release from Orthodontic Appliances by In Vivo Studies: A Systematic Literature Review

Trace Metal Release from Orthodontic Appliances by In Vivo Studies: A Systematic Literature Review,10.1007/s12011-009-8576-6,Biological Trace Element

Trace Metal Release from Orthodontic Appliances by In Vivo Studies: A Systematic Literature Review   (Citations: 3)
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The paper discusses various approaches used to investigate biocompatibility by the analysis of metals release by the materials of which orthodontic appliances are made. Analysis of various biomarkers of exposure: saliva, serum, mucosa cells, or urine is used in in vivo tests. In this work, the techniques, results, and conclusions of original papers were compared by the implementation of the concept of a systematic review. The aim of the present work was to report the state-of-the-art in the research on methods used to assess exposure to trace metals from orthodontic appliances. The PubMed search identified 35 studies, among which nine met the selection criteria. The general conclusion in the studies was that metal ions were released mostly in the initial stage of the treatment. However, the majority of studies included 1–2 months long period and did not reflect long-term changes nor the impact of the complete treatment, the duration of which is several years, on the whole organism and the overall accumulation of metals from orthodontic appliances. In studies which evaluated nickel concentrations in blood and urine, long-term metal release was detected and significant differences were found. It leads to the conclusion that nickel ions are released from orthodontic appliances in measurable amounts to human organism.
Journal: Biological Trace Element Research - BIOL TR ELEM RES , vol. 137, no. 2, pp. 127-138, 2010
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    • ...The results of in vivo studies were summarized in the previous article [9]...
    • ...Following exclusion criteria were applied: other than English papers, exposure to trace metals caused by other factors, reviews, case reports, in vivo studies (which were described in the previous study [9]), or papers concerning other topic than release of metals from orthodontic appliances in vitro, papers which evaluated ion release from the separate elements of orthodontic appliance (only—brackets, bands, and wires)...
    • ...Also, in vivo works investigated only short-term effects related with orthodontic therapy [9]...

    Marcin Mikulewiczet al. Release of Metal Ions from Orthodontic Appliances by In Vitro Studies:...

    • ...Previously, the problem of corrosion of orthodontic appliances and resulting ions release in in vitro and in vivo conditions was discussed [9, 10]...
    • ...At present, it has not been justified, if, e.g., orthodontic treatment is related with exposure to metal ions in toxic doses from biomaterials used in therapy [9, 10]...

    Marcin Mikulewiczet al. Cytocompatibility of Medical Biomaterials Containing Nickel by Osteobl...

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