Cellular Toxicity of TiO 2 Nanoparticles in Anatase and Rutile Crystal Phase

Cellular Toxicity of TiO 2 Nanoparticles in Anatase and Rutile Crystal Phase,10.1007/s12011-010-8707-0,Biological Trace Element Research,Chan Jin,Ying

Cellular Toxicity of TiO 2 Nanoparticles in Anatase and Rutile Crystal Phase   (Citations: 2)
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Titanium dioxide nanoparticles are massively produced and widely used in daily life, which has posed potential risk to human health. However, the molecular mechanism of TiO2 nanoparticles (NPs) with different crystal phases is not clear. In this study, the characterization of two crystalline phases of TiO2 NPs is evaluated by transmission electron microscopy and X-ray absorption fine structure spectrum; an interaction of these TiO2 NPs with HaCaT cells is studied in vitro using transmission electron microscopy, chemical precipitation method, and X-ray absorption fine structure spectrometry. The coordination and surface properties indicate that only the anatase–TiO2 NPs allow spontaneous reactive oxygen species (ROS) generation, but rutile–TiO2 NPs do not after dispersion. The interaction between TiO2 NPs and cellular components might also generate ROS for both anatase–TiO2 NPs and rutile–TiO2 NPs. The ROS generation could lead to cellular toxicity if the level of ROS production overwhelms the antioxidant defense of the cell or induces the mitochondrial apoptotic mechanisms. Furthermore, Ti had a direct combination with some protein or DNA after NPs enter the cell, which could also lead to cellular toxicity.
Journal: Biological Trace Element Research - BIOL TR ELEM RES , vol. 141, no. 1, pp. 3-15, 2011
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    • ...TiO2 NPs can produce free radicals and exhibit a strong oxidizing ability [4, 13, 14], then affect cellular activity...
    • ...Knowing from our previous work, the TiO2 NPs in anatase crystalline could produce ROS after dispersion [13]...
    • ...The third represents the situation where the TiO2 NPs are intruded and then create ROS products [13, 36]...

    Jin Chanet al. In Vitro Toxicity Evaluation of 25-nm Anatase TiO 2 Nanoparticles in I...

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