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Reduction of [ 18 F]Fluoromisonidazole Uptake After Neoadjuvant Chemotherapy for Head and Neck Squamous Cell Carcinoma

Reduction of [ 18 F]Fluoromisonidazole Uptake After Neoadjuvant Chemotherapy for Head and Neck Squamous Cell Carcinoma,10.1007/s11307-010-0365-2,Molec

Reduction of [ 18 F]Fluoromisonidazole Uptake After Neoadjuvant Chemotherapy for Head and Neck Squamous Cell Carcinoma   (Citations: 2)
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Purpose  The purpose of this study was to investigate the changes of tumor hypoxia as a result of neoadjuvant chemotherapy (NAC) by measuring the changes of [18F]fluoromisonidazole ([18F]FMISO) positron emission tomography (PET) uptake, as well as to look into the ability of [18F]FMISO PET to predict the NAC result. Procedures  A total of 13 patients with locally advanced head and neck squamous cell carcinoma underwent [18F]FMISO PET scans before and after NAC. For analysis of PET index, maximum standardized uptake value, tumor-to-muscle ratio, and hypoxic volume (HV) were measured. Results  All PET indexes of [18F]FMISO significantly decreased after NAC. Although HV in primary tumor and a few indexes before NAC in responder was lower than that in nonresponder, none of the indexes were statistically significant. Conclusions  Pretreatment [18F]FMISO could not predict NAC outcome in this study. However, [18F]FMISO uptake significantly decreased after NAC, and [18F]FMISO PET seemed to be a useful noninvasive tool for detecting hypoxia reduction after NAC.
Journal: Molecular Imaging and Biology - MOL IMAGING BIOL , vol. 13, no. 2, pp. 227-231, 2011
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