Prenatal protein depletion and Δ9, Δ6 and Δ5 desaturases in the rat

Prenatal protein depletion and Δ9, Δ6 and Δ5 desaturases in the rat,10.1007/BF02533523,Lipids,Osvaldo Mercuri,María Elena de Tomás,Herminia Itarte

Prenatal protein depletion and Δ9, Δ6 and Δ5 desaturases in the rat   (Citations: 14)
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Pregnant rats were kept throughout gestation on a control diet (i.e., 25% protein), on a low protein diet (i.e., 5% protein) or on a fat-free diet. At 20–21 days of gestation, the rate of 9-, 6-, and 5-desaturation was measured, using microsomes from maternal and fetal livers and placenta microsomes. The effect of protein malnutrition was more evident upon Δ6-desaturase activity from maternal liver, while a less severe reduction in the activities of Δ9- and Δ5-desaturases was observed. No measurable activities of Δ5- and Δ6-desaturases were observed in fetal liver and placenta, while a low activity of Δ9-desaturase was detected in both tissues from the three groups under study. We concluded that Δ6-desaturation is greatly affected by maternal protein deprivation, and this fact could affect the normal supply of polyunsaturated fatty acids for the normal fetus growth and tissue development.
Journal: Lipids , vol. 14, no. 9, pp. 822-825, 1979
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    • ...More recently, Mercuri and coworkers (9, 10) showed that partial deprivation of protein during early development in the rat is associated with a decreased ratio of arachidonate to hinoleate in liver phospholipids (PL), as a consequence of the marked reduction in the activities of the enzymes involved in the biosynthesis of arachidonic acid from linoleic acid...
    • ...If i�6 desaturase is decreased as a consequence of protein malnutrition (9, 10), the elongation of 18:2w6 to 20:2w6 may be expected to increase...
    • ...In recent experiments Mercuri and coworkers (9, 10) demonstrated that protein deficiency during early development of the rat could account for the decrease in the content of arachidonic acid, despite a normal content of linoleic acid in liver PL, consistent with a reduction in the activity of �6-desaturase and the observed decrease in I 8:3.o6...

    Ralph T Holmanet al. Essential fatty acid deficiency in malnourished children13

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