Author | Conference | Journal | Organization | Year | DOI
Look for results that meet for the following criteria:
Academic
Publications
Cognitive function correlates with frontal white matter apparent diffusion coefficients in patients with leukoaraiosis

Cognitive function correlates with frontal white matter apparent diffusion coefficients in patients with leukoaraiosis,10.1007/s00415-008-0661-9,Journ

Edit
Cognitive function correlates with frontal white matter apparent diffusion coefficients in patients with leukoaraiosis   (Citations: 4)
BibTex | RIS | RefWorks Download
Background and aims   Diffusion weighted imaging (DWI) displays a high sensitivity to white matter changes, even in areas where no lesions are visible. Correlation with vascular risk factors and cognitive dysfunction seems to be feasible using this technique. We aimed to test relations between age, blood pressure and cognitive function,with lesion load and average Apparent Diffusion Coefficient (ADC) values in lesioned (LWM) and in normal appearing white matter (NAWM), in patients with age related white matter lesions (ARWML). Methods   Subjects were 29 patients (mean age 72.6 ± 5.2 years) with different severity of ARWML on MRI and no (or mild) disability assessed by the Instrumental Activities of Daily Living Scale. Imaging lesion load was quantified in bilateral frontal, temporal, parieto-occipital, basal ganglia and infratentorial regions, using a simple visual rating scale; ADC was measured bilaterally in Regions of Interest in parieto-occipital and frontal NAWM, and in frontal periventricular LWM. Neuropsychological examination consisted of Raven Colored Progressive Matrices, Rey’s Complex Figure, Digit Canceling. Symbol digit Substitution, Inverse Digit Repetition and Verbal Fluency tests. Results   Visual scales scores and ADC were significantly higher in frontal and parieto-occipital regions. Both were significantly correlated to age and blood pressure, in frontal (visual scale scores and ADC) and parieto-occipital regions (ADC). Attention skills were negatively correlated to ADC in LWM and NAWM in frontal regions and with frontal region visual scale scores. Conclusion   Our findings suggest that severity of white matter ischemic changes is correlated with worse cognitive function, as well as advanced age and higher blood pressure.A higher vulnerability of frontal white matter to vascular disease seems to play an important role in executive dysfunction, mainly determined by impairment of attentional skills.DWI results suggest this could be true even for NAWM.
Journal: Journal of Neurology - J NEUROL , vol. 255, no. 3, pp. 360-366, 2008
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
More »
    • ...There existed a significant association between white matter lesion load and severity of DTI and MTR measures in the normalappearing white matter with the microstructural changes in normal brain tissue being more closely related to the patients’ clinical presentation than the volume of visible white matter abnormalities [9, 32, 52, 61, 69, 70, 74, 92, 93]...

    Reinhold Schmidt, et al. Heterogeneity in age-related white matter changes

Sort by:

Citations (4)

Share this on