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Association between serum amyloid A and obesity: a meta-analysis and systematic review

Association between serum amyloid A and obesity: a meta-analysis and systematic review,10.1007/s00011-010-0163-y,Inflammation Research,Yulan Zhao,Xuel

Association between serum amyloid A and obesity: a meta-analysis and systematic review   (Citations: 4)
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Background  Emerging evidence indicates an association of the acute-phase protein serum amyloid A (SAA) with obesity. Here we review and summarize quantitatively the available data related to this association. Methods  PubMed was systematically searched using the terms “serum amyloid A” and “obesity.” Eighty-one relevant studies between January 1966 and July 2009 were identified. Of these, only 11 cross-sectional studies and 10 prospective studies with successful interventions met our inclusion criteria for the meta-analysis. All analyses were conducted using the Comprehensive Meta-Analysis software. Literature pertaining to the relationship between SAA and other inflammatory markers, and the association between SAA and obesity-related disorders, such as cardiovascular diseases, atherosclerosis, diabetes, and insulin resistance was also reviewed. Results  A strong association between body mass index and SAA levels was found in the 11 cross-sectional studies. The overall correlation coefficient is 0.230 (95% CI 0.160–0.297, P < 0.0005). The ten prospective studies were subsequently analyzed, and the difference in SAA levels before and after weight loss, expressed as standardized mean difference was −0.480 (95% CI −0.678 to −0.283, P < 0.0005). We discuss some potential underlying mechanisms and clinical applications for reducing SAA levels in obesity.
Journal: Inflammation Research - INFLAMM RESEARCH , vol. 59, no. 5, pp. 323-334, 2010
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