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Antagonism between tilidine and naloxone on cerebral potentials and pain ratings in man

Antagonism between tilidine and naloxone on cerebral potentials and pain ratings in man,10.1016/0014-2999(83)90082-1,European Journal of Pharmacology,

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Antagonism between tilidine and naloxone on cerebral potentials and pain ratings in man   (Citations: 15)
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Journal: European Journal of Pharmacology - EUR J PHARMACOL , vol. 87, no. 4, pp. 431-439, 1983
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    • ...Human experimental studies applying local anesthesia, cortical potentials, and sensorimotor reflexes emphasize appropriate noxious stimulation by this kind of electrode (Bromm et al. 1983; Bromm and Meier 1984; Kaube et al. 2000; Katsarava et al. 2006)...

    Kerstin Jung, et al. Heterotopic low-frequency stimulation induces nociceptive LTD within t...

    • ...Naloxone when administered by the oral route is rapidly metabolized by the liver (3); however, it has been reported that at doses higher than 15 mg per os it can still block the central effect of opioids in morphine-depende nt subjects (4, 5) and in healthy volunteers (6)...
    • ...Existing pharmacologic data on these drugs indicate that naloxone per os is rapidly metabolized by the liver in about 30 rain (3), its antagonistic effect on the central nervous system starts 30-60 min after ingestion (4, 6), and its duration of action is dose-dependent (5)...

    G. Basilisco, et al. Oral naloxone antagonizes loperamide-induced delay of orocecal transit

    • ...Thus, the dependence producing potential of tilidine (Jasinski and Nutt 1973; McCarthy and Harrigan 1976; Beil and Trojan 1976, 1977; Wieck et al. 1977; Keup 1983) is reduced by the addition of naloxone (Brinkhoff and Peters-H/irtel 1978; Gabka 1978; Geisler et al. 1978; Krell and Hanke 1979; Brinkhoff 1981 ; Koelle et al. 1981 ; Bromm et al. 1983; Herrmann 1983; Herrmann et al. 1984)...

    F. Hoffmeister. Negative reinforcing properties of naloxone in the non-dependent rhesu...

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