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Oral self-administration of γ-hydroxybutyric acid in the rat

Oral self-administration of γ-hydroxybutyric acid in the rat,10.1016/0014-2999(95)00493-5,European Journal of Pharmacology,Giancarlo Colombo,Roberta A

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Oral self-administration of γ-hydroxybutyric acid in the rat   (Citations: 28)
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The present study describes the induction of γ-hydroxybutyric acid (GHB) preference over water in rats. GHB solution (1% w / v in water) was initially offered as the sole fluid available for 14 consecutive days. Subsequently, rats were given a free choice of GHB solution and tap water for 20 consecutive weeks. Under the free-choice regimen, all rats showed periods of preference for GHB solution over water and periods of voluntary abstinence from GHB. On GHB-preference days, GHB was ingested at pharmacologically relevant doses. GHB intake occurred in 2–3 discrete episodes during the nocturnal phase. The development of an animal model of GHB self-administration may constitute a useful tool in the investigation of the neurobiological substrates of GHB-reinforcing properties.
Journal: European Journal of Pharmacology - EUR J PHARMACOL , vol. 285, no. 1, pp. 103-107, 1995
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