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Evolution of new protein function: recombinational enhancer Fis originated by horizontal gene transfer from the transcriptional regulator NtrC

Evolution of new protein function: recombinational enhancer Fis originated by horizontal gene transfer from the transcriptional regulator NtrC,10.1016

Evolution of new protein function: recombinational enhancer Fis originated by horizontal gene transfer from the transcriptional regulator NtrC   (Citations: 13)
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New protein function is thought to evolve mostly by gene duplication and divergence. Here we present phylogenetic evidence that the multifunctional protein Fis of the γ proteobacterial species derived from the COOH-terminal domain of an ancestral α proteobacterial NtrC transcriptional regulatory protein. All of the known enterobacterial fis genes are preceded by an open reading frame, named yhdG, that is highly similar to nifR3, a gene that forms an operon with ntrC in several α proteobacterial species. Thus, we propose that yhdG and fis were acquired by a lineage ancestral to the γ proteobacteria in a single horizontal gene transfer event, and later diverged to their present functions.
Journal: Febs Letters - FEBS LETT , vol. 433, no. 1, pp. 108-112, 1998
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