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Immunogenicity and immunomodulatory effects of amnion-derived multipotent progenitor cells

Immunogenicity and immunomodulatory effects of amnion-derived multipotent progenitor cells,10.1016/j.humimm.2008.04.007,Human Immunology,Richard Allan

Immunogenicity and immunomodulatory effects of amnion-derived multipotent progenitor cells   (Citations: 7)
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Journal: Human Immunology - HUM IMMUNOL , vol. 69, no. 6, pp. 321-328, 2008
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    • ...Moreover, in allogeneic and xenogeneic mixed lymphocyte tests, these cells suppress the T-cell response [23], suggesting that they can be used in human transplantation, where a realistic utilization of cell therapy is in an allogeneic donor-to-host context...
    • ...cells, which express little to no MHC class I antigen in the undifferentiated state [68–71]; as well, multipotent cells isolated from fetal membranes and placenta, secondtrimester amniotic fluid and amnion membrane showed to be negative for MHC II expression [23, 72, 73] and fetal membranes-derived progenitor cells demonstrated not to induce a cytotoxic response and inhibit lymphocyte proliferation in a mixed allogeneic lymphocyte test ...
    • ...Such a study is motivated by the fact that in the stem cells from the amnion (collected at term) both the mesenchymal and epithelial layers seem to be endowed with immuno-modulatory properties [22, 23] and are suitable for xenogeneic [13] and allogeneic [12] transplantation for the cell therapy of cardiac diseases...

    Sveva Bolliniet al. In Vitro and In Vivo Cardiomyogenic Differentiation of Amniotic Fluid ...

    • ...On the other hand, Banas and colleagues [12] demon strated that the immunomodulatory eff ect of AE cells is dependent on cell-to-cell contact with responding T cells...

    Toshio Miki. Amnion-derived stem cells: in quest of clinical applications

    • ...Unlike most stem cells, AMP cells have been demonstrated to be nontumorigenic and nonimmunogenic [4]...

    Wyatt G. Payneet al. Effect of Amnion-Derived Cellular Cytokine Solution on Healing of Expe...

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