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Epitope-vaccine as a new strategy against HIV1 mutation

Epitope-vaccine as a new strategy against HIV1 mutation,10.1016/S0165-2478(01)00187-0,Immunology Letters,Yi Xiao,Yun Lu,Ying-Hua Chen

Epitope-vaccine as a new strategy against HIV1 mutation   (Citations: 15)
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An effective vaccine is urgently needed to stop AIDS-epidemic. Up to now none of the candidate HIV-vaccines has been developed to prevent HIV-1 infection. A few neutralizing antibodies against HIV-1 enveloping proteins proved to be highly effective to neutralize different strains in vitro. Unfortunately, these antibodies are rare in infected humans, and have never yet been raised by a vaccine. The multiple sequential and antigenic variability of HIV-1 led to unprecedented difficulties in development of effective vaccines and anti-viral drugs. More and more experimental evidences indicated that HIV-1 mutants resulted in immune evasion may be a grave challenge for conventional strategy to prepare effective vaccines. We suggested that epitope-vaccine could be a new strategy to induce high levels of neutralizing antibodies with predefined epitope-specificity against HIV-1. Several candidate epitope-vaccines including mono-epitope-vaccine, multi-epitope-vaccine, epitope-vaccines in combination, were prepared and systematically studied in animal experiments. These studies provided experimental evidences that epitope-vaccine could be a new strategy to develop effective vaccines for prevention and immunotherapy against viral infection of HIV-l or other viruses.
Journal: Immunology Letters - IMMUNOL LETT , vol. 77, no. 1, pp. 3-6, 2001
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