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Epitope vaccine: a new strategy against HIV1

Epitope vaccine: a new strategy against HIV1,10.1016/S0167-5699(99)01560-1,Immunology Today,Ying-Hua Chen,Yi Xiao,Tianwei Yu,Manfred P Dierich

Epitope vaccine: a new strategy against HIV1   (Citations: 24)
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Journal: Immunology Today - IMMUNOL TODAY , vol. 20, no. 12, pp. 588-589, 1999
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    • ...The epitope-vaccine approach has been suggested as a strategy to circumvent the rapid rate of mutations in HIV- 1 and the subsequent viral escape from the host's immune system as well as the development of resistance to antiviral drugs [12-14]...
    • ...Several strategies can be used to develop multi-epitope vaccines, including (a) the generation of tetramer epitope vaccines with epitopes being chosen based on the presence of principal neutralizing determinant [12], (b) the generation of synthetic peptides with prediction of the candidate epitopes based on the peptide binding affinity of anchor residues in silico, focusing on those capable of binding to multiple HLA alleles [17], (c) the ...

    Sinu Paulet al. Discovery of novel targets for multi-epitope vaccines: Screening of HI...

    • ... while we suggested that an epitope vaccine is a new antiviral strategy [...

    Yun Luet al. A Candidate Vaccine against Influenza Virus Intensively Improved the I...

    • ...reviewed problems in studies of rgp120 subunit vaccine and found that this vaccine was unsuccessful because it induced very weak neutralization activity against representative primary viral isolates, and indicated that a new strategy must be chosen to solve these problems. We suggested to use an epitope vaccine to induce high levels of neutralizing antibodies against HIV–1 infection [...

    Yun Luet al. Immunogenicity of Neutralizing Epitopes on Multiple–Epitope Vaccines a...

    • ...We recently suggested a new concept that an epitope vaccine could represent a new strategy against HIV-1 [...

    Yi Xiaoet al. Induction of High Levels of Antibodies Recognizing the Neutralizing Ep...

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