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The third function of the thymus

The third function of the thymus,10.1016/S0167-5699(99)01559-5,Immunology Today,Benedict Seddon,Don Mason

The third function of the thymus   (Citations: 114)
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Nonresponsiveness of mammalian T cells to self-antigens is not totally accounted for in terms of clonal deletion, T-cell anergy and T-cell ignorance: studies have shown that the T-cell repertoire of healthy individuals contains cells with the potential to cause autoimmune disease. This article describes a T-cell-mediated mechanism that prevents the realization of this potential and indicates how its failure can lead to the development of autoimmunity.
Journal: Immunology Today - IMMUNOL TODAY , vol. 21, no. 2, pp. 95-99, 2000
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