Author | Conference | Journal | Organization | Year | DOI
Look for results that meet for the following criteria:
Academic
Publications
Antimicrobial activities of LL37 and its truncated variants against Burkholderia thailandensis

Antimicrobial activities of LL37 and its truncated variants against Burkholderia thailandensis,10.1016/j.ijantimicag.2010.06.031,International Journal

Edit
Antimicrobial activities of LL37 and its truncated variants against Burkholderia thailandensis   (Citations: 2)
BibTex | RIS | RefWorks Download
Antimicrobial peptides (AMPs) are essential host defence molecules found in a wide variety of species and are promising antibacterial therapeutic candidates. Focusing on the human cathelicidin peptide LL-37, the aim of the present study was to explore the mechanisms of action and antimicrobial activities of a library of LL-37 fragments using Burkholderia thailandensis E264 as a model. The results revealed that IG-19 was the shortest fragment within LL-37 that exhibited antibacterial activity. LL-31, missing six residues at the C-terminus of LL-37, exhibited the strongest killing effect. Freeze-fracture electron microscopy of bacterial cells treated with either LL-37 or LL-31 revealed irregular bacterial surfaces with bleb projections, indicating that these peptides disrupted the integrity of the membrane. In addition, these peptides induced leakage of cell components, including nucleotides and even proteins. Altogether, the results obtained indicate the potential of using LL-31 as a new AMP to combat Burkholderia spp.
Journal: International Journal of Antimicrobial Agents - INT J ANTIMICROBIAL AGENTS , vol. 36, no. 5, pp. 447-452, 2010
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
Sort by:

Citations (2)

Share this on