IL1β during in vitro decidualization in primate

IL1β during in vitro decidualization in primate,10.1016/S0165-0378(01)00141-3,Journal of Reproductive Immunology,Z Strakova,S Srisuparp,A. T Fazleabas

IL1β during in vitro decidualization in primate   (Citations: 7)
BibTex | RIS | RefWorks Download
The sequence of biochemical and molecular events associated with decidualization in the primate remain unclear. In the baboon, the sequential changes during this period in vivo are characterized by the downregulation of α-smooth actin followed by induction of cyclooxygenase-2 (COX-2) at the implantation site and the expression of insulin growth factor binding protein-1 (IGFBP-1). IGFBP-1 is the predominant protein in decidualized cells and is considered to be biochemical marker of decidualization. In the baboon the expression of IGFBP-1 requires the presence of a conceptus in vivo or N6, 2′-O-dibutyryladenosine 3:5′-cyclic monophosphate (dbcAMP) in the presence of hormones in vitro. In addition IL-1β, as a possible conceptus-mediated factor, can induce IGFBP-1 expression in the presence of hormones following 3 days of incubation. However, if IL-1β and dbcAMP are added together, IGFBP-1 expression is inhibited which resulted in IL-1β being considered to be ‘inhibitory’ to decidualization. Current data suggest that IL-1β can activate multiple signaling pathways that either positively (no exogenous cAMP) or negatively (in presence of exogenous cAMP) regulate IGFBP-1 gene expression and decidualization in vitro. Signaling pathways activated by IL-1β following 10 min of stimulation result in the phosphorylation of mitogen-activated protein kinase (MAPK, specifically p38 MAPK) and also lead to NF-κB activation. The expression of COX-2 and matrix metalloproteinase-3 (MMP-3) genes follows after 4–6 h. The steroid hormones, particularly progesterone, which are critical for IGFBP-1 expression, modulate the activity of IL-1β by down-regulating MMP-3 activity. Disruption of actin filaments enhances IGFBP-1 induction during decidualization. IL-1β induced MMP-3 may upregulate IGFBP-1 by initiation of cytoskeletal reorganization through degradation of extracellular matrix (ECM). Inhibition of IL-1β induced pathways leads to reduction of IGFBP-1 expression, suggesting that IL-1β may be involved in the events leading to decidualization in baboons.
Journal: Journal of Reproductive Immunology - J REPROD IMMUNOL , vol. 55, no. 1, pp. 35-47, 2002
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
    • ...The NF-B pathway is known to play a role in the baboon endometrium during decidualization (48)...
    • ...Current data suggest that IL-1 activates multiple signaling pathways that either positively (in the absence of exogenous cAMP) or negatively (in presence of exogenous cAMP) regulate decidualization and IGFBP-1 gene expression in vitro, involving NF-B activation as well as phosphorylation of p38 MAPK (48)...

    Emily P. Tierneyet al. Activation of the protein kinase A pathway in human endometrial stroma...

Sort by: