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Effects of acute ischemia, early extrabeats and propafenone on complex activation patterns in intact and ischemic canine hearts

Effects of acute ischemia, early extrabeats and propafenone on complex activation patterns in intact and ischemic canine hearts,10.1016/S0024-3205(03)

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Effects of acute ischemia, early extrabeats and propafenone on complex activation patterns in intact and ischemic canine hearts  
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Although, sodium channel blockers have the ability to suppress nonsustained ventricular arrhythmias, an excessive drug-associated arrhythmic death rate has been reported in patients with coronary heart disease (CHD). Sodium channel blockers should prevent initiation of reentry activation by reducing directional differences in cardiac conduction (anisotropy). However, in vitro data demonstrated, that reduction of membrane excitability, e.g. by lowering the inward Na+ current, increases the risk for conduction failure and associated reentry arrhythmias. In 11 dogs the effects of myocardial ischemia, premature epicardial stimulation (PES) and propafenone on anisotropic conduction properties were tested using three-dimensional mapping techniques. The epicardial (longitudinal and transverse to fiber orientation) and transmural (oblique and straight) spread of activation was reconstructed during constant and PES. At baseline, conduction velocities (CV) were higher along (1.20 ± 0.41 m/s) than across (0.91 ± 0.19 m/s; p
Journal: Life Sciences - LIFE SCI , vol. 72, no. 24, pp. 2751-2767, 2003
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