Academic
Publications
Association study between single nucleotide polymorphisms in promoter region of AVPR1A and Korean autism spectrum disorders

Association study between single nucleotide polymorphisms in promoter region of AVPR1A and Korean autism spectrum disorders,10.1016/j.neulet.2010.05.0

Association study between single nucleotide polymorphisms in promoter region of AVPR1A and Korean autism spectrum disorders   (Citations: 1)
BibTex | RIS | RefWorks Download
So Young Yang, Soo-Churl Cho, Hee Jeong Yoo, In Hee Cho, Mira Park, Boong-Nyun Kim, Jae-Won Kim, Min-Sup Shin, Tae-Won Park, Jung-Woo Son, Un-Sun Chung, Hyo-Won Kimhttp://academic.research.microsoft.com/io.ashx?type=5&id=35418031&selfId1=0&selfId2=0&maxNumber=12&query=
To determine the association between arginine vasopressin receptor 1A gene (AVPR1A) and autism spectrum disorders (ASDs), we examined 3 single nucleotide polymorphisms (SNPs), namely, rs7294536, rs3759292, and rs10877969, in the promoter region of AVPR1A by using a family-based association test (FBAT) in 151 Korean trios. Our results demonstrated a statistically significant association between autism and SNPs (additive model: rs7294536, χ2=9.328, df=2, P=0.002; rs10877969, χ2=11.529, df=2, P<0.001) as well as between autism and haplotype analysis (additive model: χ2=14.122, df=3, P=0.003). In addition, we found that ADI-R scores calculated by using a diagnostic algorithm for failure to develop peer relationships (A2) were higher in subjects having the AA genotype than in subjects having the AG and GG genotypes of rs7294536. Thus, our study provides evidence for a possible association between these SNPs and the phenotype of ASDs.
Journal: Neuroscience Letters - NEUROSCI LETT , vol. 479, no. 3, pp. 197-200, 2010
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
Sort by: