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Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates

Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates,10.1016/j.addr.2010.03.003,Advanced Drug Delivery Reviews,Jung

Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates   (Citations: 5)
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Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.
Journal: Advanced Drug Delivery Reviews - ADVAN DRUG DELIVERY REV , vol. 62, no. 6, pp. 592-605, 2010
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    • ...In particular, during the last decade the field of nanotechnology has reached important progresses and a wide range of organic and inorganic nanomaterials are now available as experimental contrast agents for various imaging modalities, with an incredible amount of further possible combinations with other compounds, like, for instance, binding agents to specific cellular targets [5,6]...

    A. Grecoet al. Improving automatic segmentation of tissue-targeted nanoparticles on e...

    • ... the introduction of novel non-ionizing techniques for medical imaging at cellular and molecular level, allowing earlier and safer disease diagnoses and the improvement of accuracy and effectiveness of therapies through their integration in the diagnostic procedure itself, thanks to the possibility of loading specific drugs on nanoparticles acting both as contrast agents and as targeted therapeutic vectors (“theranostic” approach) [2],[3]...

    G. Solopertoet al. Advanced spectral analysis for automatic echographic monitoring of an ...

    • ...Aptamers are short, three-dimensional synthetic RNA or DNA oligonucleotides (15-40 nucleotides long) or peptides (10-20 amino acids long) that bind their target with high affinity and specificity, hence their nickname of ‘chemical antibodies’ [89-91]...
    • ...This lacuna is easily remedied by chemical modifications of the aptamers, making them ideal candidate for novel nanotherapeutics with improved targeting power and therapeutic index [90]...
    • ...For instance, they have played a crucial role in increasing targeting and imaging of cancer cell and their associated vasculature by being coupled to metallic nanoparticles such as magnetic, gold and ruby-eye doped nanoparticles, as well as quantum dots [90,92-94]...

    Deboshri Banerjeeet al. Nanotechnology-mediated targeting of tumor angiogenesis

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