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Pharmacological activation of 5HT 7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity

Pharmacological activation of 5HT 7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity,10.1016/j.pain.2010.03.007,Pain,Ale

Pharmacological activation of 5HT 7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity   (Citations: 2)
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Alex Brenchat, Xavier Nadal, Luz Romero, Sergio Ovalle, Asunción Muro, Ricard Sánchez-Arroyos, Enrique Portillo-Salido, Marta Pujol, Ana Montero, Xavier Codony, Javier Burgueño, Daniel Zamanillohttp://academic.research.microsoft.com/io.ashx?type=5&id=35646650&selfId1=0&selfId2=0&maxNumber=12&query=
The involvement of the 5-HT7 receptor in nociception and pain, particularly chronic pain (i.e., neuropathic pain), has been poorly investigated. In the present study, we examined whether the 5-HT7 receptor participates in some modulatory control of nerve injury-evoked mechanical hypersensitivity and thermal (heat) hyperalgesia in mice. Activation of 5-HT7 receptors by systemic administration of the selective 5-HT7 receptor agonist AS-19 (1 and 10mg/kg) exerted a clear-cut reduction of mechanical and thermal hypersensitivities that were reversed by co-administering the selective 5-HT7 receptor antagonist SB-258719. Interestingly, blocking of 5-HT7 receptors with SB-258719 (2.5 and 10mg/kg) enhanced mechanical (but not thermal) hypersensitivity in nerve-injured mice and induced mechanical hypersensitivity in sham-operated mice. Effectiveness of the treatment with a 5-HT7 receptor agonist was maintained after repeated systemic administration: no tolerance to the antiallodynic and antihyperalgesic effects was developed following treatment with the selective 5-HT7 receptor agonist E-57431 (10mg/kg) twice daily for 11days. The 5-HT7 receptor co-localized with GABAergic cells in the dorsal horn of the spinal cord, suggesting that the activation of spinal inhibitory GABAergic interneurons could contribute to the analgesic effects of 5-HT7 receptor agonists. In addition, a significant increase of 5-HT7 receptors was found by immunohistochemistry in the ipsilateral dorsal horn of the spinal cord after nerve injury, suggesting a “pain”-triggered regulation of receptor expression. These results support the idea that the 5-HT7 receptor subtype is involved in the control of pain and point to a new potential use of 5-HT7 receptor agonists for the treatment of neuropathic pain.
Journal: Pain , vol. 149, no. 3, pp. 483-494, 2010
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