Academic
Publications
Concentration-dependent differential induction of necrosis or apoptosis by HIV1 lytic peptide 1

Concentration-dependent differential induction of necrosis or apoptosis by HIV1 lytic peptide 1,10.1016/S0196-9781(99)00132-1,Peptides,Douglas R Plyma

Concentration-dependent differential induction of necrosis or apoptosis by HIV1 lytic peptide 1   (Citations: 10)
BibTex | RIS | RefWorks Download
The mechanism by which human immunodeficiency virus type 1 induces depletion of CD4+ T-lymphocytes remains controversial, but may involve cytotoxic viral proteins. Synthetic peptides (lentivirus lytic peptide type 1) corresponding to the carboxyl terminus of the human immunodeficiency virus type 1 transmembrane glycoprotein induce cytopathology at concentrations of 100 nM and above. At these concentrations lentivirus lytic peptide type 1 disrupts mitochondrial integrity of CD4+ T-lymphoblastoid cells and induces other changes characteristic of necrosis. In contrast, at concentrations of 20 nM, lentivirus lytic peptide type 1 potently induces apoptosis. Thus, the mechanism by which human immunodeficiency virus type 1 mediates cell death, necrosis or apoptosis, may depend, in part, on the tissue concentration of transmembrane glycoprotein.
Journal: Peptides , vol. 20, no. 11, pp. 1275-1283, 1999
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
    • ...The LLP domains of HIV TM also have the capacity to interact with membranes and alter permeability [18,29]...

    Bongkun Choiet al. Alterations in intracellular potassium concentration by HIV1 and SIV N...

    • ...Functionally, LLP-1 and -2 can lyse bacteria, fungus, red blood cells, and various cultured eukaryotic cells [1,11,16-21]...
    • ...Prior observations that LLP-1 can bind to intracellular signalling molecules, such as calmodulin to ultimately induce apoptosis and/or necrosis [16,18,19,56] suggest that the LLP domains may be configured in certain situations to be associated exclusively with the inner leaflet of the lipid membrane where they are able to interact with these intracellular molecules (see Figure 5B)...

    Joshua M Costinet al. Viroporin potential of the lentivirus lytic peptide (LLP) domains of t...

    • ...In particular, gp41-derived LLP-1 has been shown to disrupt mitochondrial integrity of CD4 C T-lymphoblastoid cells, inducing the cell death cascade that culminates in apoptosis or necrosis depending on the concentration of peptide employed (Plymale et al, 1999a)...
    • ...Further experiments are required to elucidate the morphological or biochemical changes characteristic of apoptosis, which could occasionally occur in cells exposed to higher concentration of LLP-1 (Plymale et al, 1999a)...

    Ji Hye Sunget al. Protective effect of glutathione in HIV1 lytic peptide 1-induced cell ...

Sort by: