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Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks

Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks,10.1002/(SICI)1097-4636(200008)51:2<164::AID-JBM4>3.0.

Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks   (Citations: 150)
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A photopolymerizing hydrogel system provides an efficient method to encapsulate cells. The present work describes the in vitro analysis of bovine and ovine chondro- cytes encapsulated in a poly(ethylene oxide)-dimethacrylate and poly(ethylene glycol) semi-interpenetrating network us- ing a photopolymerization process. One day after encapsu- lation, (3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyl-2H- tetrazolium bromide) (MTT) and light microscopy showed chondrocyte survival and a dispersed cell population com- posed of ovoid and elongated cells. Biochemical analysis demonstrated proteoglycan and collagen contents that in- creased over 2 weeks of static incubation. Cell content of the gels initially decreased and stabilized. Biomechanical analy- sis demonstrated the presence of a functional extracellular matrix with equilibrium moduli, dynamic stiffness, and streaming potentials that increased with time. These find- ings suggest the feasibility of photoencapsulation for tissue engineering and drug delivery purposes. © 2000 John Wiley & Sons, Inc. J Biomed Mater Res, 51, 164-171, 2000.
Journal: Journal of Biomedical Materials Research - J BIOMED MATER RES , vol. 51, no. 2, pp. 164-171, 2000
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