Academic
Publications
Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty

Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty,10.1016/j.mad.2008.09.013,Mecha

Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty   (Citations: 16)
BibTex | RIS | RefWorks Download
Frailty is a state of health signified by an increased vulnerability to adverse health outcomes in the face of stressors (e.g. infection). There is emerging consensus that research on both the theory and measurement of frailty must focus on the dynamic interactions within and across systems underlying the frailty syndrome. In this paper, we propose a dynamical systems modeling approach, based on the stimulus-response experimental paradigm, to propel future advances in the study of frailty. Our proposal is novel in that it provides a quantitative framework to operationalize and test the core notion underlying frailty that it signifies a loss of resilience in homeostatic regulation. The proposed framework offers many important benefits, including (a) insights into whether and how homeostatic regulation differs between frail and non-frail older adults, (b) identification of critical regulatory systems, if they exist, that could function as sentinel systems for screening and early detection of frailty, (c) establishment of the value of provocative tests that can provide maximal information on the integrity of systems identified in (b), and (d) evaluation and unification of diverse empirical descriptions of frailty by providing a mathematical framework anchored in quantifying the loss of resilience, an essential property of frailty.
Journal: Mechanisms of Ageing and Development - MECH AGE DEV , vol. 129, no. 11, pp. 666-670, 2008
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
Sort by: