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Cell locations for AQP1, AQP4 and 9 in the non-human primate brain
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Cell locations for AQP1, AQP4 and 9 in the non-human primate brain   (Citations: 4)
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The presence of three water channels (aquaporins, AQP), AQP1, AQP4 and AQP9 were observed in normal brain and several rodent models of brain pathologies. Little is known about AQP distribution in the primate brain and its knowledge will be useful for future testing of drugs aimed at preventing brain edema formation. We studied the expression and cellular distribution of AQP1, 4 and 9 in the non-human primate brain. The distribution of AQP4 in the non-human primate brain was observed in perivascular astrocytes, comparable to the observation made in the rodent brain. In contrast with rodent, primate AQP1 is expressed in the processes and perivascular endfeet of a subtype of astrocytes mainly located in the white matter and the glia limitans, possibly involved in water homeostasis. AQP1 was also observed in neurons innervating the pial blood vessels, suggesting a possible role in cerebral blood flow regulation. As described in rodent, AQP9 mRNA and protein were detected in astrocytes and in catecholaminergic neurons. However additional locations were observed for AQP9 in populations of neurons located in several cortical areas of primate brains. This report describes a detailed study of AQP1, 4 and 9 distributions in the non-human primate brain, which adds to the data already published in rodent brains. This relevant species differences have to be considered carefully to assess potential drugs acting on AQPs non-human primate models before entering human clinical trials.
Journal: Neuroscience , vol. 167, no. 4, pp. 1103-1114, 2010
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    • ...These findings appear consistent across species, but recently Arciénaga et al. [8] have demonstrated a more widespread distribution of AQP1 in non-human primates including white matter astrocytes, Schwann cells along oculomotor and trigeminal nerves as well as in neurons on the surface of pial blood vessels...
    • ...A third aquaporin, AQP9, is also found within the CNS but is limited to small populations of catecholaminergic neurons as well as in astrocytes in cortical grey matter and hippocampus [8,9]...

    Brian K Owler, et al. Aquaporins: relevance to cerebrospinal fluid physiology and therapeuti...

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