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C-type natriuretic peptide: new candidate for endothelium-derived hyperpolarising factor

C-type natriuretic peptide: new candidate for endothelium-derived hyperpolarising factor,10.1016/j.biocel.2003.09.009,International Journal of Biochem

C-type natriuretic peptide: new candidate for endothelium-derived hyperpolarising factor   (Citations: 10)
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Endothelium-derived hyperpolarising factor (EDHF) is an important regulator of vascular tone; however, its identity is still unclear. Several different molecules have been suggested, the most recent of which is the 22-amino acid peptide C-type natriuretic peptide (CNP). CNP induces hyperpolarisation and relaxation of rat mesenteric resistance artery vascular smooth muscle through activation of natriuretic peptide receptor subtype C (NPR-C) and the same potassium channels as EDHF. In addition, this peptide is released from endothelial cells of the perfused rat mesenteric bed in response to endothelium-dependent vasodilators. Thus, CNP is likely to play a vital role in regulation of vascular tone. In addition, since there is evidence that up-regulation of EDHF occurs where normal endothelium function has been compromised, modulation of this pathway represents a novel target for therapeutics in the treatment of inflammatory cardiovascular pathologies characterised by endothelial dysfunction.
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    • ...As previously mentioned that the neutrophil surface density of neutral endopeptidase was significantly higher in BD patients.[35] CNP is deactivated and metabolized after hydrolysis by neutral endopeptidase, which is found in high concentrations on the luminal surface of endothelial cells [48]...
    • ...Neutral endopeptidase exhibits a higher rate of hydrolysis of CNP compared to other NPs [39], and CNP is the most sensitive to this deactivation [48]...

    Ramazan Yağcıet al. Serum levels of natriuretic peptides in patients with Behcet’s disease

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