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Multiple mechanisms of fast excitatory synaptic transmission in the enteric nervous system

Multiple mechanisms of fast excitatory synaptic transmission in the enteric nervous system,10.1016/S0165-1838(00)00130-2,Journal of The Autonomic Nerv

Multiple mechanisms of fast excitatory synaptic transmission in the enteric nervous system   (Citations: 69)
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The enteric nervous system (ENS) can control gastrointestinal function independent of direct connections with the central nervous system. Enteric nerves perform this important function using multiple mechanisms of excitatory neurotransmission in enteric ganglia. Fast excitatory synaptic transmission in the autonomic nervous system (ANS) is largely mediated by acetylcholine (ACh) acting at nicotinic cholinergic receptors but in the ENS there are noncholinergic fast excitatory neurotransmitters. There are two broad types of neurons in the ENS: S neurons and AH neurons. S neurons are interneurons and motoneurons while AH neurons are sensory neurons. Three subsets of S neurons in the myenteric plexus can be distinguished on the basis of the neurotransmitters producing fast excitatory postsynaptic potentials (fEPSPs) in each subset. In one subset, fEPSPs are mediated solely by ACh acting at nicotinic cholinergic receptors. In a second subset of S neurons, ATP acting at P2X purine receptors and ACh contribute to the fEPSP while in a third subset, fEPSPs are mediated by 5-hydroxytryptamine (5-HT) acting at 5-HT3 receptors and ACh. Some AH neurons also receive fast excitatory synaptic input. The fEPSPs recorded from AH neurons are mediated ACh and also by glutamate acting at alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors. Multiple mechanisms of fast excitatory synaptic transmission in the ENS are likely to contribute to its capacity to regulate complex gastrointestinal functions.
Journal: Journal of The Autonomic Nervous System - J AUTONOM NERV SYST , vol. 81, no. 1, pp. 97-103, 2000
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    • ..., and were so named because they display fast excitatory postsynaptic potentials mediated by nicotinic acetylcholine receptors and P2X receptor...

    Nancy Osorioet al. Patch clamp recording from enteric neurons in situ

    • ...In the enteric plexus ATP functions as a neurotransmitter mediating fast-excitatory synaptic transmission (ESPSs; Galligan et al. 2000), and is involved in intrinsic enteric reXex pathways associated with motor complex formation (Brierley et al. 2001)...

    Christine Kestleret al. Distribution of P2X 3 receptor immunoreactivity in myenteric ganglia o...

    • ...In the ENS, ATP activates P2Y and P2X receptors to cause slow and fast membrane depolarizations, respectively, in S/type 1 neurons of the submucosal plexus of the guinea pig ileum (Barajas-Lopez et al. 1994; LePard and Galligan 1999; Galligan et al. 2000; Ren et al. 2003; Hu et al. 2003; Monro et al. 2004)...
    • ...The P2X receptors have been shown to play an important role in synaptic transmission within the neural pathways mediating motor activity in the intestine (Katayama and Morita 1989; Kimball et al. 1996; Heinemann et al. 1999; LePard and Galligan 1999; Bian et al. 2000; Galligan et al. 2000; Spencer et al. 2000; Ren et al. 2003) and the non-cholinergic portion of fast excitatory postsynaptic potentials are mediated by P2X receptors, with ...

    Zhenghua Xianget al. Distribution of P2Y 2 receptors in the guinea pig enteric nervous syst...

    • ...This finding has led to the hypothesis that P2X receptors are one of the mediators of fast excitatory post-synaptic potentials (EPSPs) in the ENS (Galligan and Bertrand 1994; LePard and Galligan 1999; Galligan et al. 2000)...

    Huai Zhen Ruanet al. The distribution of P2X 5 purinergic receptors in the enteric nervous ...

    • ...These include ACh (Steele et al., 1991; Li and Furness, 1998; Neunlist et al., 1999; Cooke, 2000; Furness, 2000; Galligan et al., 2000), norepinephrine (NE) (Leibl et al., 1999), 5-HT (Gershon, 2000), GABA (Krantis, 2000), and glutamate (Liu et al., 1997; Kirchgessner, 2001)...

    Zhishan Liet al. Enteric dopaminergic neurons: Definition, developmental lineage, and e...

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