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Caspases: killer proteases

Caspases: killer proteases,10.1016/S0968-0004(97)01085-2,Trends in Biochemical Sciences,Donald W. Nicholson,Nancy A. Thornberry

Caspases: killer proteases   (Citations: 1080)
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Caspases (cysteinyl aspartate-specific proteinases) mediate highly specific proteolytic cleavage events in dying cells, which collectively manifest the apoptotic phenotype. The key and central role that these enzymes play in a biochemical cell-suicide pathway has been conserved throughout the evolution of multicellular eukaryotes.
Journal: Trends in Biochemical Sciences - TRENDS BIOCHEM SCI , vol. 22, no. 8, pp. 299-306, 1997
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