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Spontaneous losses of control of cytokeratin gene expression in transformed, non-epithelial human cells occurring at different levels of regulation

Spontaneous losses of control of cytokeratin gene expression in transformed, non-epithelial human cells occurring at different levels of regulation,10

Spontaneous losses of control of cytokeratin gene expression in transformed, non-epithelial human cells occurring at different levels of regulation   (Citations: 59)
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Journal: Cell , vol. 59, no. 1, pp. 67-79, 1989
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    • ...In view of the general problems of heterogeneities of cell type and differentiation state in fresh cell cultures and in cell culture lines derived from mesenchymal tissues, including stem cell cultures (see Knapp et al. 1989; Knapp and Franke 1989 ;f or a recent review, see Ho et al. 2008), we decided to examine and characterize the mesenchymal cells of the valve interior in various mammalian species, both in situ and in cell cultures...

    Mareike Barthet al. Cordial connections: molecular ensembles and structures of adhering ju...

    • ...The cloning of individual cells and establishment of subclone cell cultures were essentially as described for diverse other cell cultures (Knapp and Franke 1989; Knapp et al. 1989)...
    • ...These and several other gene expression experiments have led us to the conclusion that the emergence of the synthesis of VEcadherin is not a trivial and widespread result of “loose” or “leaky” gene control, as has been reported for other cytoskeletal proteins in diverse cell cultures (e.g., Knapp and Franke 1989; Knapp et al. 1989; and references cited therein) but is the result of specific gene induction in these glioma cells...
    • ...U333 and generated clonal sublines (for methods, see Knapp and Franke 1989)...

    Judit Boda-Heggemannet al. Beyond vessels: occurrence and regional clustering of vascular endothe...

    • ...Therefore, we regarded these syntheses of certain cytoskeletal proteins and their assembly to filamentous structures as being representative of subclasses of cells and cell clones characterized by the loss of control of gene expression (e.g., Knapp and Franke 1989) and not as being evidence for the heterogeneity of cell differentiation and fate...

    Patrick Wuchteret al. Processus and recessus adhaerentes : giant adherens cell junction syst...

    • ...15 can represent true keratin expression, comparable to the acquisition of K8 and K18 in transformed cells through deregulation of keratin expression, as previously reported for cultured transformed fibroblasts...

    Julie C Fanburg-Smithet al. Keratin expression in schwannoma; a study of 115 retroperitoneal and 2...

    • ...However, as the aberrant expression of cytokeratin genes has been detected in transformed cells of nonepithelial origin (20), it can be postulated that this also occurs following transformation by T. annulata...

    Brian R. Shielset al. A Theileria annulata DNA Binding Protein Localized to the Host Cell Nu...

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