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Dual Roles for Patched in Sequestering and Transducing Hedgehog

Dual Roles for Patched in Sequestering and Transducing Hedgehog,10.1016/S0092-8674(00)81374-4,Cell,Yu Chen,Gary Struhl

Dual Roles for Patched in Sequestering and Transducing Hedgehog   (Citations: 309)
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Secreted proteins of the Hedgehog (Hh) family have diverse organizing roles in animal development. Recently, a serpentine protein Smoothened (Smo) has been proposed as a Hh receptor. Here, we present evidence that implicates another multiple-pass transmembrane protein, Patched (Ptc), in Hh reception and suggests a novel signal transduction mechanism in which Hh binds to Ptc, or a Ptc–Smo complex, and thereby induces Smo activity. Our results also show that Ptc limits the range of Hh action; we provide evidence that high levels of Ptc induced by Hh serve to sequester any free Hh and therefore create a barrier to its further movement.
Journal: Cell , vol. 87, no. 3, pp. 553-563, 1996
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