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Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer's Disease

Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer's Disease,Teresa Gomez-Isla,Joseph L. Price,Daniel W. McKeel Jr,John

Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer's Disease   (Citations: 443)
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mildest clinically detectable dementia (CDR 5 0.5), all of whom had sufficient neurofibrillary tangles (NFTs) and senile plaques for the neuropathological diagnosis of AD, had 32% fewer EC neurons than controls. Decreases in individual lamina were even more dramatic, with the number of neurons in layer II decreasing by 60% and in layer IV by 40% compared with controls. In the severe dementia cases (CDR 5 3), the number of neurons in layer II decreased by ;90%, and the number of neurons in layer IV decreased by ;70% compared with con- trols. Neuronal number in AD was inversely proportional to NFT formation and neuritic plaques, but was not related significantly to diffuse plaques or to total plaques. These results support the conclusion that a marked decrement of layer II neurons distin- guishes even very mild AD from nondemented aging.
Published in 1996.
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