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The role of MeCP2 in CNS development and function

The role of MeCP2 in CNS development and function,10.1016/j.yhbeh.2010.05.014,Hormones and Behavior,Elisa S. Na,Lisa M. Monteggia

The role of MeCP2 in CNS development and function   (Citations: 2)
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Rett syndrome is a neurodevelopmental disorder that is a direct consequence of functional mutations in the methyl-CpG-binding protein-2 (MeCP2) gene, which has focused attention on epigenetic mechanisms in neurons. MeCP2 is widely believed to be a transcriptional repressor although it may have additional functions in the CNS. Genetic mouse models that compromise MeCP2 function demonstrate that homeostatic regulation of MeCP2 is necessary for normal CNS functioning. Recent work has also demonstrated that MeCP2 plays an important role in mediating synaptic transmission in the CNS in particular, spontaneous neurotransmission and short-term synaptic plasticity. This review will discuss the role of MeCP2 in CNS development and function, as well as a potential important role for MeCP2 and epigenetic processes involved in mediating transcriptional repression in Rett syndrome.
Journal: Hormones and Behavior - HORMONE BEHAV , vol. 59, no. 3, pp. 364-368, 2011
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