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Antiproliferative activity and apoptosis-inducing mechanism of Concanavalin A on human melanoma A375 cells

Antiproliferative activity and apoptosis-inducing mechanism of Concanavalin A on human melanoma A375 cells,10.1016/j.abb.2008.12.003,Archives of Bioch

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Antiproliferative activity and apoptosis-inducing mechanism of Concanavalin A on human melanoma A375 cells   (Citations: 14)
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The objective of this study was to investigate the antiproliferative activity and apoptosis-inducing mechanism of Concanavalin A (ConA) on human melanoma A375 cells. We firstly simulated the three-dimensional structure of ConA. Subsequently, we found that ConA possessed remarkable antiproliferative effect on A375 cells. Further experimental data indicated that there was a link between its hemagglutinating activity, mannose-binding activity and antiproliferative activity. In addition, we showed that ConA induced A375 cell apoptosis in a caspase-dependent manner. Then, we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential (MMP) collapse, cytochrome c release and caspase activation. In conclusion, we report for the first time that there may be a close correlation between carbohydrate-binding activity of ConA and its antiproliferative activity. Also, we demonstrate firstly that ConA induces A375 cell death in a caspase-dependent manner as well as through a mitochondrial apoptotic pathway.
Journal: Archives of Biochemistry and Biophysics - ARCH BIOCHEM BIOPHYS , vol. 482, no. 1, pp. 1-6, 2009
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