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One year variability of peak heights, heterozygous balance and inter-locus balance for the DNA positive control of AmpF ℓ STR © Identifiler © STR kit

One year variability of peak heights, heterozygous balance and inter-locus balance for the DNA positive control of AmpF ℓ STR © Identifiler © STR kit,

One year variability of peak heights, heterozygous balance and inter-locus balance for the DNA positive control of AmpF ℓ STR © Identifiler © STR kit  
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Multivariate analyses of 205 positive control experiments in an AmpFℓSTR© Identifiler© STR kit were used to analyze the factors affecting peak heights at 16 loci. Peak heights were found to be highly correlated between loci and there was evidence for a difference in sensitivity of the two genetic analyzers in the blue channel. Heterozygous balance response at 10 loci was found to behave as a random variable following a beta-distribution with typical median values of 90%, without locus or genetic analyzer effect. Inter-locus balance at 16 loci was influenced by the blue channel effect and a temporal switch of unexplained origin. The implications of these results for the choice of minimum threshold values in quality control are discussed.
Journal: Forensic Science International-genetics - FORENSIC SCI INT-GENET , vol. 5, no. 1, pp. 43-49, 2011
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