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Nuclear functions of the HMG proteins

Nuclear functions of the HMG proteins,10.1016/j.bbagrm.2009.09.001,Biochimica Et Biophysica Acta-gene Regulatory Mechanisms,Raymond Reeves

Nuclear functions of the HMG proteins   (Citations: 3)
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Although the three families of mammalian HMG proteins (HMGA, HMGB and HMGN) participate in many of the same nuclear processes, each family plays its own unique role in modulating chromatin structure and regulating genomic function. This review focuses on the similarities and differences in the mechanisms by which the different HMG families impact chromatin structure and influence cellular phenotype. The biological implications of having three architectural transcription factor families with complementary, but partially overlapping, nuclear functions are discussed.
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    • ...HMGA proteins affect the expression of many genes through architectural remodeling of the chromatin structure and by stabilizing nucleoprotein complexes called enhanceosomes built on promoter/enhancer regions [7,8]...
    • ...In addition, HMGA proteins are part of further chromatin complexes, as has been shown for the pre-replication complex [9] and are able to influence the structure and function of large chromatin domains [8,10]...
    • ...HMGA proteins participate in specific gene expression, for example the formation of enhanceosomes [8], binding to specific promoter regions to remove inhibitory factors and to recruit chromatin remodeling complexes or to interact with other transcription factors (e.g...

    Jan Brocheret al. HMGA1 down-regulation is crucial for chromatin composition and a gene ...

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