Academic
Publications
A Cohort of Balanced Reciprocal Translocations Associated with Dyslexia: Identification of Two Putative Candidate Genes at DYX1

A Cohort of Balanced Reciprocal Translocations Associated with Dyslexia: Identification of Two Putative Candidate Genes at DYX1,10.1007/s10519-010-938

A Cohort of Balanced Reciprocal Translocations Associated with Dyslexia: Identification of Two Putative Candidate Genes at DYX1   (Citations: 3)
BibTex | RIS | RefWorks Download
Dyslexia is one of the most common neurodevelopmental disorders where likely many genes are involved in the pathogenesis. So far six candidate dyslexia genes have been proposed, and two of these were identified by rare chromosomal translocations in affected individuals. By systematic re-examination of all translocation carriers in Denmark, we have identified 16 different translocations associated with dyslexia. In four families, where the translocation co-segregated with the phenotype, one of the breakpoints concurred (at the cytogenetic level) with either a known dyslexia linkage region—at 15q21 (DYX1), 2p13 (DYX3) and 1p36 (DYX8)—or an unpublished linkage region at 19q13. As a first exploitation of this unique cohort, we identify three novel candidate dyslexia genes, ZNF280D and TCF12 at 15q21, and PDE7B at 6q23.3, by molecular mapping of the familial translocation with the 15q21 breakpoint.
Journal: Behavior Genetics - BEHAV GENET , vol. 41, no. 1, pp. 125-133, 2011
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
    • ...Rare variant approaches hold out significant promise particularly in examining particular familial pedigrees or in concerted focus on more significantly impaired individuals (e.g., Elbert et al. 2011; Buonincontri et al. 2011; Rubenstein et al. 2011; Svensson et al. 2011)...
    • ...(For examples, see the following papers in this issue: Elbert et al. 2011; Bates et al. 2011; Buonincontri et al. 2011; Docherty et al. 2011; Marino et al. 2011; Matsson et al. 2001; Newbury et al. 2011; Czamara et al. 2011; Svensson et al. 2011; Venkatesh et al. 2011) and to inform our understanding of risk particularly for recent immigrants...

    Brett MillerPeggy McCardleet al. Moving Closer to a Public Health Model of Language and Learning Disabi...

    • ... More recently, a Danish Cytogenetic Registry study of all cases with chromosomal translocations identified additional novel dyslexia candidate genes affirming the value of rare structural variants in understanding the genetics of dyslexia ...

    Santhosh Girirajanet al. Relative Burden of Large CNVs on a Range of Neurodevelopmental Phenoty...

Sort by: