Academic
Publications
Conserved structural elements in the V3 crown of HIV1 gp120

Conserved structural elements in the V3 crown of HIV1 gp120,10.1038/nsmb.1861,Nature Structural & Molecular Biology,Xunqing Jiang,Valicia Burke,Maxim

Conserved structural elements in the V3 crown of HIV1 gp120   (Citations: 13)
BibTex | RIS | RefWorks Download
Binding of the third variable region (V3) of the HIV-1 envelope glycoprotein gp120 to the cell-surface coreceptors CCR5 or CXCR4 during viral entry suggests that there are conserved structural elements in this sequence-variable region. These conserved elements could serve as epitopes to be targeted by a vaccine against HIV-1. Here we perform a systematic structural analysis of representative human anti-V3 monoclonal antibodies in complex with V3 peptides, revealing that the crown of V3 has four conserved structural elements: an arch, a band, a hydrophobic core and the peptide backbone. These are either unaffected by or are subject to minimal sequence variation. As these regions are targeted by cross-clade neutralizing human antibodies, they provide a blueprint for the design of vaccine immunogens that could elicit broadly cross-reactive protective antibodies.
Journal: Nature Structural & Molecular Biology - NAT STRUCT MOL BIOL , vol. 17, no. 8, pp. 955-961, 2010
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
Sort by: