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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses,10.1038/ni1087,Nature Immunology,Mitsutoshi

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses   (Citations: 933)
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Intracellular double-stranded RNA (dsRNA) is a chief sign of replication for many viruses. Host mechanisms detect the dsRNA and initiate antiviral responses. In this report, we identify retinoic acid inducible gene I (RIG-I), which encodes a DExD/H box RNA helicase that contains a caspase recruitment domain, as an essential regulator for dsRNA-induced signaling, as assessed by functional screening and assays. A helicase domain with intact ATPase activity was responsible for the dsRNA-mediated signaling. The caspase recruitment domain transmitted 'downstream' signals, resulting in the activation of transcription factors NF-κB and IRF-3. Subsequent gene activation by these factors induced antiviral functions, including type I interferon production. Thus, RIG-I is key in the detection and subsequent eradication of the replicating viral genomes.
Journal: Nature Immunology - NAT IMMUNOL , vol. 5, no. 7, pp. 730-737, 2004
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