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The second wave in kinase cancer drugs

The second wave in kinase cancer drugs,10.1038/nbt0206-127,Nature Biotechnology,Ken Garber

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The second wave in kinase cancer drugs   (Citations: 19)
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Journal: Nature Biotechnology - NAT BIOTECHNOL , vol. 24, no. 2, pp. 127-130, 2006
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    • ...The family of genes most frequently contributing to cancer is the Protein Kinase gene family [4] which is implicated in a huge number of tumorigenic functions including immune evasion, proliferation, antiapoptotic activity, metastasis and angiogenesis, possibly due to the simplicity of the mechanism of attaching an ATP-derived phosphate to a substrate protein [5]...

    Jose MG Izarzugaza, et al. Characterization of pathogenic germline mutations in human Protein Kin...

    • ... 3), and as such may be used as targets for future pharmaceutical interventio...

    Piya Lahiry, et al. Kinase mutations in human disease: interpreting genotype–phenotype rel...

    • ... The increasing availability of large assay panel...

    Mazen W Karaman, et al. A quantitative analysis of kinase inhibitor selectivity

    • ...The family of genes most frequently contributing to cancer is the protein kinase gene family (1), which are both implicated in, and confirmed as drug targets for, a number of tumorigenic functions, including, immune evasion, proliferation, antiapoptotic activity, metastasis, and angiogenesis (2, 3). As mutations accumulate in a precancerous cell, some mutations confer a selective advantage by contributing to tumorigenic functions (known as ...
    • ...These predictions will be particularly important in protein kinases, which are major participants in tumor progression and especially important targets for pharmaceutical intervention (2, 3). Thus, the large number of observed somatic mutations in protein kinases (4) and their importance in tumorigenesis substantiate the value of a specialized method capable of highly accurate predictions within the protein kinase gene family...

    Ali Torkamani, et al. Prediction of Cancer Driver Mutations in Protein Kinases

    • ...Currently, kinase inhibitors Gleevec and Herceptin represent the most powerful therapies (Garber, 2006; Lim, 2005; Moasser, 2007)...

    Predrag Radivojac, et al. Gain and loss of phosphorylation sites in human cancer

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