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The origin of eukaryotes: a reappraisal

The origin of eukaryotes: a reappraisal,10.1038/nrg2071,Nature Reviews Genetics,Christian de Duve

The origin of eukaryotes: a reappraisal   (Citations: 27)
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Ever since the elucidation of the main structural and functional features of eukaryotic cells and subsequent discovery of the endosymbiotic origin of mitochondria and plastids, two opposing hypotheses have been proposed to account for the origin of eukaryotic cells. One hypothesis postulates that the main features of these cells, including their ability to capture food by endocytosis and to digest it intracellularly, were developed first, and later had a key role in the adoption of endosymbionts; the other proposes that the transformation was triggered by an interaction between two typical prokaryotic cells, one of which became the host and the other the endosymbiont. Re-examination of this question in the light of cell-biological and phylogenetic data leads to the conclusion that the first model is more likely to be the correct one.
Journal: Nature Reviews Genetics - NAT REV GENET , vol. 8, no. 5, pp. 395-403, 2007
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    • ... It might even provide a model for adaptations that originally selected for a nucleus and endomembrane system (for example, the model suggested by De Duve for the evolution of endomembranes in eukaryote...

    Evgeny Sagulenkoet al. Beyond the bacterium: planctomycetes challenge our concepts of microbi...

    • ...Even the most widely accepted notion that eukaryotes originated from prokaryotes is problematic because traits unique to eukaryotes, such as the nucleus, endomembrane system, cytoskeleton, and mitosis, are found in all taxa with no intermediate stages left as signposts of their evolution [1-3]...
    • ...eukaryotes (e.g., an “archezoan” )t hat engulfed and retained the alphaproteobacterium via endosymbiosis [1-4]...
    • ...The central importance of the mitochondrion to eukaryogenesis is recognized by alternative hypotheses that posit the acquisition of the mitochondrial forerunner by an archaeon host as the founding event of eukaryotic evolution (e.g., the hydrogen hypothesis) [1,2,6]...
    • ...This “mitochondrion as seed” perspective fails however to satisfactorily explain how the mitochondrial forerunner gained entry into the host cell in the absence of phagocytosis and how the evolution of eukaryotic complexity evolved after this critical event [2,3]...
    • ...Despite this deep-rooted view, modern cell biology demonstrates that the NE is morphogenetically derived from the endoplasmic reticulum (ER) [2,26]...
    • ...Proponents of “phagocytosis first” hypotheses suggest that the endomembrane system emerged as an organized endocytic pathway that eventually differentiated into the proto-ER [2,47]...
    • ...Mitochondria, the aerobic buffer of the eukaryotic cell Was phagocytosis required for acquisition of the alphaproteobacterial endosymbiont precursor of mitochondria [1-4]? If phagocytosis is a derived property of the endomembrane system and cytoskeleton that consumes high amounts of ATP [5], the opposite is likely to have occurred; i.e., the aerobic mitochondrion was required for the evolution of phagocytosis...
    • ...The idea that eukaryogenesis and alphaproteobacterial acquisition involved syntrophic symbiosis in the context of biofilms has been proposed more than once in the literature [2,6,53-55]...
    • ...Signatures of aerobic eukaryogenesis The heterogeneous phylogenetic affiliation of the eukaryotic proteome provides a conundrum in traditional theories of eukaryogenesis [1,2,34]...
    • ...This resulted in a phylogenetic profile that is characterized by a large number of eukaryotic specific proteins [2,80] and a substantial fraction of eukaryotic operational proteins (e.g., metabolic enzymes) that have a eubacterial rather than archaeal provenance [1,2,34]...
    • ...This resulted in a phylogenetic profile that is characterized by a large number of eukaryotic specific proteins [2,80] and a substantial fraction of eukaryotic operational proteins (e.g., metabolic enzymes) that have a eubacterial rather than archaeal provenance [1,2,34]...
    • ...In contrast, informational proteins (e.g., those involved in gene expression, transcription, and translation) were less affected by replacements via HGT or EGT because they supported fundamental infrastructural functions in the newly evolved eukaryotic cell, and were therefore vertically inherited from the archaeal ancestor [1,2,34]...
    • ...The plasma membrane of Archaea is based on glycerophospholipids comprised of ether linked isoprenoid chains [2]...
    • ...However the interpretation that the endomembrane system emanates from a rudimentary endocytic pathway that first evolved to engulf microparticles of food [2], seems to us more realistic and worthy of serious discussion, although this idea likewise contradicts the fact that the biogenesis and morphogenesis of the endomembrane system in based on an exocytic pathway...

    Jeferson Grosset al. Uniting sex and eukaryote origins in an emerging oxygenic world

    • ...In a highly-cited and controversial [8-12] paper, Rivera & Lake [13] used trees based on gene content logdet distance to support a new theory about the origins of eukaryotes...

    Ajanthah Sangaralingamet al. On the artefactual parasitic eubacteria clan in conditioned logdet phy...

    • ...jpg" NDATA ITEM> ]>

      A hallmark of eukaryotic cells is the presence of a nucleus and the bioenergetic organelles — the mitochondrion and the plastid, which originated from Gram-negative bacterial progenitors that once resided inside a eukaryotic 'host' cell as endosymbionts and were converted over time into bona fide organelle...

    Jeferson Grosset al. Mitochondrial and plastid evolution in eukaryotes: an outsiders' persp...

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