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The functional plasticity of T cell subsets

The functional plasticity of T cell subsets,10.1038/nri2654,Nature Reviews Immunology,Jeffrey A. Bluestone,Charles R. Mackay,John J. O'Shea,Brigitta S

The functional plasticity of T cell subsets   (Citations: 21)
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In 1986, Robert Coffman and Timothy Mossman first described the division of CD4+ T cells into functional subsets, termed T helper 1 (TH1) and TH2, based on cytokine production, and in doing so unwittingly opened a Pandora's box of complexity and controversy. Although the mechanisms that regulate TH1 and TH2 cells are now well known, recent descriptions of other CD4+ T cell subsets — such as regulatory T cells, T follicular helper cells, TH17, TH22 and most recently TH9 and TH22 cells — have questioned how we think of T cell subsets and what commitment to a functional T cell subset means. Here, Nature Reviews Immunology asks four leaders in the field their thoughts on the functional plasticity of T cell subsets.
Journal: Nature Reviews Immunology - NAT REV IMMUNOL , vol. 9, no. 11, pp. 811-816, 2009
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