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Different Mechanisms of CDK5 and CDK2 Activation as Revealed by CDK5/p25 and CDK2/Cyclin A Dynamics

Different Mechanisms of CDK5 and CDK2 Activation as Revealed by CDK5/p25 and CDK2/Cyclin A Dynamics,10.1074/jbc.M509699200,Journal of Biological Chemi

Different Mechanisms of CDK5 and CDK2 Activation as Revealed by CDK5/p25 and CDK2/Cyclin A Dynamics   (Citations: 13)
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Journal: Journal of Biological Chemistry - J BIOL CHEM , vol. 281, no. 11, pp. 7271-7281, 2006
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    • ...The first docking study, which was published 10 years ago, involved eight inhibitors, and the authors concluded that they had not found any statistically significant relationship between the activity (IC50) and the interaction energy (using the DOCK score [59]) because of the low correlation coefficient (r 2 = 0.15) [60]...

    Petr Dobeset al. Transferable scoring function based on semiempirical quantum mechanica...

    • ... CDK5 differs from most other kinases, including other CDKs, in this respect: the apoenzyme is in a constitutively active form, and catalytic activity is enhanced following binding of regulatory partners such as p25 and p35 (Ref...

    Michael P. Mazanetzet al. Untangling tau hyperphosphorylation in drug design for neurodegenerati...

    • ...The structural explanation for lack of phosphorylation is that Ser159 forms favourable contacts with the p25 CBF domain that are expected to contribute to the stability of the interaction (Otyepka et al., 2006; Tarricone et al., 2001)...
    • ...The precise contacts that allow the p35/p39 CBF to achieve this effect remain unclear, but it seems plausible that the extensive interactions of the p35 CBF with the CDK activation loop must be important (Otyepka et al., 2006; Tarricone et al., 2001)...

    Andrea Musacchio. The Structural Bases of CDK5 Activity

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