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Phosphorylation of Connexin43 on Serine368 by Protein Kinase C Regulates Gap Junctional Communication

Phosphorylation of Connexin43 on Serine368 by Protein Kinase C Regulates Gap Junctional Communication,10.1083/jcb.149.7.1503,Journal of Cell Biology,P

Phosphorylation of Connexin43 on Serine368 by Protein Kinase C Regulates Gap Junctional Communication   (Citations: 138)
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Journal: Journal of Cell Biology - J CELL BIOL , vol. 149, no. 7, pp. 1503-1512, 2000
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    • ...Because Cx43 is known to be phosphorylated by PKCε [11, 18], our study examined whether Epac activation was able to increase Cx43 phosphorylation...
    • ...It has been shown to be phosphorylated by PKC on a specific residue, Ser368 [18]...
    • ...The increase in intercellular permeability observed by FRAP in association with the increase in phosphorylation of Cx43 was surprising since most previous studies found a decrease in intercellular communication induced by Cx43 phosphorylation on ser368 [1, 18]...

    Nicolas Duquesneset al. Epac stimulation induces rapid increases in connexin43 phosphorylation...

    • ...We observe similar results with PMA treatments, a positive control for PKC phosphorylation at threonine 505 and Cx43 phosphorylation at serine 368 [19]...
    • ...(GST-Cx43CT). We anticipated association of PKCδ with the C-terminal tail of Cx43 because this domain is commonly associated with the assembly of signal complexes [15-18] and includes characterized PKC phosphorylation sites [19]...
    • ...Additionally, the activation of PKC isoforms, by phorbol esters has been shown to result in the inhibition of gap junctional communication [19,32-35]...

    Carla Hebertet al. Interaction of connexin43 and protein kinase C-delta during FGF2 signa...

    • ...PKC is one of the principal kinases regulating gap junctional communication (Lampe and Lau 2004; Lampe et al. 2000; Solan and Lampe 2005) as well as cell adhesion molecules (Delannoy et al. 2001; Rahman et al. 2001; Zimmerman et al. 2004)...
    • ...2003). Our observations of increased phosphorylation of Cx43 and decreased GJIC following PKC activation is consistent with previous reports in other non-neuronal cell lines (Kimura et al. 2000; Lampe et al. 2000; Ruch et al. 2001)...

    Melissa Morleyet al. PKC inhibition increases gap junction intercellular communication and ...

    • ...The reduction in dye transfer after stimulation with TPA correlates with phosphorylation of serine 368 in the Cx43 C-terminus, and mutation of this serine to alanine abolishes the effect of TPA [28]...

    Johannes P. Hofgaardet al. Phosphatidylinositol-bisphosphate regulates intercellular coupling in ...

    • ...PKC-mediated phosphorylation of Cx43 on S368 has been shown to change single channel behaviour which in turn contributes to a decrease in intercellular communication [34]...

    F. C. Howarthet al. Effects of streptozotocin-induced diabetes on connexin43 mRNA and prot...

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