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The Dam1 complex confers microtubule plus end-tracking activity to the Ndc80 kinetochore complex

The Dam1 complex confers microtubule plus end-tracking activity to the Ndc80 kinetochore complex,10.1083/jcb.200912021,Journal of Cell Biology,F. Lamp

The Dam1 complex confers microtubule plus end-tracking activity to the Ndc80 kinetochore complex   (Citations: 17)
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Journal: Journal of Cell Biology - J CELL BIOL , vol. 189, no. 4, pp. 641-649, 2010
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    • ... The N-tail of NDC80 is essential for chromosome–microtubule attachments in HeLa cells, but the corresponding budding yeast mutant is not compromised for growt...

    Fabienne Lampertet al. A blueprint for kinetochores — new insights into the molecular mechani...

    • ...In particular, recent advances are beginning to show how DASH functions at the kinetochore and how this function is regulated (Gestaut et al. 2008; Lampert et al. 2010; Tien et al. 2010)...
    • ...Two recent, independent studies demonstrate that the major role of DASH at the kinetochore may be to facilitate microtubule tip-tracking by the Ndc80 complex (Lampert et al. 2010; Tien et al. 2010)...
    • ...Both studies show, in agreement with previous work, that Ndc80 complex alone forms relatively transient associations with microtubules (Powers et al. 2009; Lampert et al. 2010; Tien et al. 2010)...
    • ...In the presence of DASH, Ndc80 forms prolonged associations with assembling and disassembling microtubule tips (Lampert et al. 2010 ;T ien et al.2010)...
    • ...In vitro studies of kinetochore–microtubule interactions have focused on interactions of kinetochore components with single microtubules (McIntosh et al. 2008; Akiyoshi et al. 2010; Lampert et al. 2010; Tien et al. 2010)...

    Graham J. Buttricket al. Ringing the changes: emerging roles for DASH at the kinetochore–microt...

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