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Detection of Active Tuberculosis Infection by T Cell Responses to Early‐Secreted Antigenic Target 6‐kDa Protein and Culture Filtrate Protein 10

Detection of Active Tuberculosis Infection by T Cell Responses to Early‐Secreted Antigenic Target 6‐kDa Protein and Culture Filtrate Protein 10,10.108

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Detection of Active Tuberculosis Infection by T Cell Responses to Early‐Secreted Antigenic Target 6‐kDa Protein and Culture Filtrate Protein 10   (Citations: 86)
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Journal: Journal of Infectious Diseases - J INFEC DIS , vol. 181, no. 5, pp. 1850-1854, 2000
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    • ...Two such antigens, early-secreted antigenic target (ESAT)- 6 and culture filtrate protein (CFP)-10, encoded in the mycobacterial genomic region of difference (RD)-1 were first evaluated in a 6-day lymphocyte stimulation test (LST) and found to be sensitive and specific for diagnosing tuberculosis (TB) [3-7]...

    Ornella Butera, et al. New tools for detecting latent tuberculosis infection: evaluation of R...

    • ...Although tuberculin skin test (TST) has long been used both in active and latent tuberculosis to support diagnosis, it has a low specificity because it may be falsely positive in BCGvaccinated subjects and may not differentiate a tuberculous from a non-tuberculous infection (4,5)...

    Oznur Ak, et al. The Evaluation of the Quantiferon-TB Gold Test in Pulmonary and Extrap...

    • ...The QFT-2G test was performed according to the manufacturer’s instructions, and the test result was judged according to CDC guidelines (5)...
    • ...There are a few reports about the usefulness of the diagnosis of patients infected with MK, M. marinum, or M. szulgai, all of which have the genes encoding both ESAT-6 and CFP- 10 antigens (1,5)...

    Yoshihiro Kobashi, et al. Clinical Usefulness of QuantiFERON TB2G Test for the Early Diagnosis o...

    • ...Paradoxically, the presence of ESAT-6 and CFP-10 in other mycobacterial species does not seem to confound the detection of M. tuberculosis- and M. bovis-associated specific responses in clinical and epidemiological practice [29,30,32,36-38], although these studies were mostly performed in low-incidence settings and patients may not have had significant previous contact with non-tuberculous mycobacteria...

    Gerald K Chege, et al. Detection of natural infection with Mycobacterium intracellulare in he...

    • ...T cell responses to ESAT-6 differ between TB patients and healthy BCG-vaccinated controls and can be used to identify symptom-free individuals recently exposed to M. tuberculosis [20-25]...
    • ...This is consistent with published studies [9,33,34] In which 55 to 95% of TB patients displayed an ESAT-6-specific Th1 response, as evaluated by lymphoproliferation assays or by determining IFN-γ concentration in the supernatant of stimulated cells [22,33]...
    • ...ESAT-6, a RD-1-encoded M. tuberculosis-specific antigen, is an accurate marker of M. tuberculosis infection; it discriminates against BCG because the RD-1 region is deleted from such strains [20- 22,24,35]...

    Valérie Martinez, et al. T-cell and serological responses to Erp, an exported Mycobacterium tub...

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