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Fibroblast Growth Factor2 Enhances Proliferation and Delays Loss of Chondrogenic Potential in Human Adult Bone-Marrow-Derived Mesenchymal Stem Cells

Fibroblast Growth Factor2 Enhances Proliferation and Delays Loss of Chondrogenic Potential in Human Adult Bone-Marrow-Derived Mesenchymal Stem Cells,1

Fibroblast Growth Factor2 Enhances Proliferation and Delays Loss of Chondrogenic Potential in Human Adult Bone-Marrow-Derived Mesenchymal Stem Cells   (Citations: 9)
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Journal: Tissue Engineering Part A - TISSUE ENG PART A , vol. 16, no. 3, pp. 1009-1019, 2010
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    • ...issues of increased passage to generate these numbers, time in culture and other potential environmental induced changes in hMSC phenotype [37-39]...

    Tracey L Bonfieldet al. Defining human mesenchymal stem cell efficacy in vivo

    • ...Fibroblast growth factor-2 (FGF-2) has been most frequently used as it was known to maintain the differentiation potential of MSCs after several mitotic divisions (Karlsson et al. 2007; Murdoch et al. 2007; Solchaga et al. 2005, 2010; Varas et al. 2007)...
    • ...Interestingly, FGF-2 treatment of MSCs during expansion has the potential to delay the loss of chondrogenic potential (Solchaga et al. 2010)...
    • ...When we performed cell expansion with growth medium supplemented with FGF-2, we obtained data consistent with the findings of other groups concerning the stimulatory effects of this growth factor on BM-MSC proliferation and differentiation (Solchaga et al. 2005, 2010; Varas et al. 2007)...
    • ...It is still not clear how FGF-2 plays a role in chondrogenesis as several signal transduction pathways might be activated in addition to the MEK/ERK (mitogen-activated protein kinase kinase/extracellular-signal regulated kinase) cascade and the Wnt signaling by FGFs stimulation described in these cells (Bobick et al. 2007; Solchaga et al. 2010)...

    Emeline Perrieret al. Analysis of collagen expression during chondrogenic induction of human...

    • ...Monolayer expansion in the presence of fibroblast growth factor-2 (FGF-2) has been shown to enhance proliferation during expansion and the subsequent chondrogenic potential of MSCs [16-19]...

    S. D. Thorpeet al. Can Dynamic Compression in the Absence of Growth Factors Induce Chondr...

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