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Suppression of Ca2+ signaling in a mouse model of Best disease

Suppression of Ca2+ signaling in a mouse model of Best disease,10.1093/hmg/ddp583,Human Molecular Genetics,Y. Zhang,J. B. Stanton,J. Wu,K. Yu,H. C. Ha

Suppression of Ca2+ signaling in a mouse model of Best disease   (Citations: 3)
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Journal: Human Molecular Genetics - HUM MOL GENET , vol. 19, no. 6, pp. 1108-1118, 2010
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    • ...CaCC currents that have been recorded in RPE cells resemble Ano1 and Ano2 currents expressed in HEK cells [89], but the expression of Anos in RPE are unexplored and their role as CaCCs responsible for LP is only speculative...
    • ...However, recently, it has been shown that a mouse harboring the W93C mutation does have an eye disease that resembles BVMD [89]...
    • ...ER. RPE cells from mBest1 knockout mice show a greater increase in intracellular Ca 2+ concentration in response to ATP than wild-type mice [40, 89], suggesting that mBest1 has an inhibitory effect on the release of Ca 2+ from internal...
    • ...The CaCC in mouse RPE cells is not changed in Best1 knockout mice and W93C Best1 knock-in mice [43, 89]...

    Qinghuan Xiaoet al. Bestrophins and retinopathies

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