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Dual-tropic HIV type 1 isolates vary dramatically in their utilization of CCR5 and CXCR4 coreceptors

Dual-tropic HIV type 1 isolates vary dramatically in their utilization of CCR5 and CXCR4 coreceptors,10.1097/QAD.0b013e32833c543f,Aids,Jonathan Toma,J

Dual-tropic HIV type 1 isolates vary dramatically in their utilization of CCR5 and CXCR4 coreceptors   (Citations: 4)
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Journal: Aids , vol. 24, no. 14, pp. 2181-2186, 2010
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    • ...= 0.024), respectively. The two dual tropic viruses (020100104 and 020100311) of subtype B′ were also very sensitive to TAK779 and maraviroc. Recent studies have demonstrated that some of the dual tropic viruses mainly used CXCR4 for entry (dual-X4), while others are much more efficient in using the CCR5 (dual-R5) ...

    Xiaoling Yuet al. Susceptibility of HIV1 Subtypes B', CRF07_BC and CRF01_AE that Are Pre...

    • ...However, analysis of larger panels of primary R5X4 HIV-1 isolates has revealed that these strains can vary dramatically in their ability to utilize either coreceptor for infection of CD4+ T cells [20, 21]...
    • ...Three R5X4 HIV-1 subsets have been identified that have preferential CCR5 or CXCR4 usage, or have equivalent use of either receptor [20]...

    Paul R. Gorryet al. Coreceptors and HIV1 Pathogenesis

    • ...Dual/ mixed-tropic populations are also present in HIV infected patients and evidence has been collected in antiretroviral-naive patients suggesting that the majority of viruses within these dual/mixed-tropic populations use CCR5 [14]...
    • ...This feature renders the cells more susceptible to infection especially by R5-tropic HIV-1 strains, which play a significant role in primary infection [14-16]...

    Elena Sartoriet al. Herpes simplex virus type 2 infection increases human immunodeficiency...

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