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Osteomalacia in institutionalized epileptic patients on long-term anticonvulsant therapy

Osteomalacia in institutionalized epileptic patients on long-term anticonvulsant therapy,10.1111/j.1600-0404.1981.tb04394.x,Acta Neurologica Scandinav

Osteomalacia in institutionalized epileptic patients on long-term anticonvulsant therapy   (Citations: 18)
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Journal: Acta Neurologica Scandinavica - ACTA NEUROL SCAND , vol. 64, no. 2, pp. 122-131, 2009
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    • ...Consistent with other studies [6, 25, 28, 31, 46, 47, 75], the results of our study supports the assumption that AED treatment is associated with significantly lower serum 25-OHD levels compared to controls...

    Sina Nettekovenet al. Effects of antiepileptic drug therapy on vitamin D status and biochemi...

    • ...Decreased vitamin D was associated with AED treatment in initial studies of bone health in persons on AEDs [5,8,10]...
    • ...Cytochrome P450 enzyme-inducing AEDs as described in both animal and human studies cause increased conversion of vitamin D to polar inactive metabolites in the liver microsomes, reducing bioavailable vitamin D. This is consistent with the observation that plasma levels of the biologically active vitamin D metabolites can be decreased in patients taking enzyme-inducing AEDs [5,8,10], leading to hypocalcemia and an increase in circulating ...

    Alison M. Pack. Bone disease in epilepsy

    • ...Among the pathophysiologic changes are bone diseases such as osteomalacia [1, 2]. Recent studies have also described reduced bone mineral density in CBZ-treated patients compared to healthy controls [3–5]...

    S. Brämswiget al. Carbamazepine Does Not Alter Biochemical Parameters of Bone Turnover i...

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