Teratogenicity of Antiepileptic Drugs: Analysis of Possible Risk Factors

Teratogenicity of Antiepileptic Drugs: Analysis of Possible Risk Factors,10.1111/j.1528-1157.1988.tb03746.x,Epilepsia,Sunao Kaneko,Koichi Otani,Yutaka

Teratogenicity of Antiepileptic Drugs: Analysis of Possible Risk Factors   (Citations: 84)
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Journal: Epilepsia , vol. 29, no. 4, pp. 459-467, 1988
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    • ...AED CombinationsIn only 60% of epilepsy patients, monotherapy is sufficient to obtain adequate seizure control. About 40% of patients require treatment with more than 1 AED. Although the individual compounds have been amply tested for teratogenic effects in animal models before a license for human use is accorded, this is not the case for the various combinations of AEDs. Therefore observational studies are of great importance to evaluate the safety of AED combinations. A number of studies demonstrated increased risks of major congenital malformations after the exposure to AED combinations. Associations have been found between the risk of major congenital malformations and the number of AEDs taken, and the specific combinations and the relative dose of each drug within these combinations [,,,,,,...

    K. ten Berget al. Antiepileptic Drugs in Pregnancy: Options for the Prevention of Congen...

    • ...yet women are at increased risk of adverse outcomes. Congenital malformations have been the most commonly reported events and several studies support a teratogenic role for AEDs....

    N Adabet al. Additional educational needs in children born to mothers with epilepsy

    • ...However, the observation of a more frequent presence of malformations in children exposed to VPA in combination with other drugs suggests that polytherapy may play a major role also in this case [62-64]...

    Francesco Pisani. Influence of co-medication on the metabolism of valproate

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