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In Situ Deposition of Complement in Human Acute Brain Ischaemia

In Situ Deposition of Complement in Human Acute Brain Ischaemia,10.1111/j.1365-3083.2009.02253.x,Scandinavian Journal of Immunology,E. D. Pedersen,E.

In Situ Deposition of Complement in Human Acute Brain Ischaemia   (Citations: 5)
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Journal: Scandinavian Journal of Immunology - SCAND J IMMUNOL , vol. 69, no. 6, pp. 555-562, 2009
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    • ...In humans, the role of complement in ischemic stroke is less clear. Complement is activated locally in the human brain in the course of ischemic stroke as the deposits of both early complement components (C1q, C3c and C4d) and terminal complex (C5b-9) were found in the infarcts [...

    Anna Stokowskaet al. Plasma C3 and C3a Levels in Cryptogenic and Large-Vessel Disease Strok...

    • ...The complement cascade is an important part of the innate immune system and is a potent mediator of inflammation and cell lysis which is activated following cerebral ischemia [5-7], and strong complement activation after ischemic stroke is associated with unfavourable outcomes [8]...
    • ...Recent studies indicated that both, the classical and the mannose-binding lectin (MBL) complement pathways trigger complement activation [6,34,35], but the alternative pathway also appears to play a crucial role in neuronal death [36,37]...
    • ...It was recently shown that ischemia leads to a rapid loss of membranous CD59 protein in the ischemic core region [41,6]...

    Denise Harhausenet al. Membrane attack complex inhibitor CD59a protects against focal cerebra...

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